Pharmacological properties of mangiferin

Mangiferin (1,3,6,7-tetrahydroxy-2-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]xanthen-9-one) is a naturally occurring polyphenol in several fruits, one being Mangifera indica L., one of the most popular tropical fruit bearing trees in the world.

Mango leaves have been used by traditional medicine of a number of peoples for centuries. The key biological substance in them is a polyphenol called mangiferin. Mangiferin commonly used as antioxidant for medical purposes.

Mangiferin inhibited the hydroxyl radicals by 84.3 % at 37 °С and 79.8 % at 80°С, as it showed a higher antioxidant activity than quercetine.

Mango leaves

Mangiferin is a heat stable molecule and it possesses antioxidant, antidiarrhea, dyslipidemic, anti-diabetic, antibacterial and anticancer activities.

Studies have suggested that Mangiferin also has an in vitro anticancer effect in cellular lines of acute myeloid leukemia. It was also reported Mangiferin as a promising natural product with benefits as analgesic, anti-sclerotic, antiviral, cardio and hepatoprotective, anti-allergic, monoamine oxygenase (MAO) inhibitor, and protector against UV radiation.

These polyphenols of mangiferin exhibit antioxidant properties and tend to decrease the oxygen-free radicals, thereby reducing the DNA damage. Indeed, its capability to modulate several key inflammatory pathways undoubtedly helps installing the progression of carcinogenesis.
Pharmacological properties of mangiferin